Roles of HTLV-1 Tax in Leukemogenesis of Human T-Cells
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Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia (ATL), which is an aggressive form of T-cell malignancy. HTLV-1 oncoproteins, Tax and HBZ, play crucial roles in the immortalization of T-cells and/or leukemogenesis by dysregulating the cellular functions in the host. Recent studies show that HTLV-1-infected T-cells have reduced expression of the BCL1...
متن کاملHBZ and its roles in HTLV-1 oncogenesis
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, ...
متن کاملHTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10.
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), and the viral oncoprotein Tax plays key roles in the immortalization of human T cells, lifelong persistent infection, and leukemogenesis. We herein identify the ubiquitin-specific protease 10 (USP10) as a Tax-interactor in HTLV-1-infected T cells. USP10 is an antistress factor against various en...
متن کاملHTLV-I Tax regulates the cellular proliferation through the down-regulation of PIP3-phosphatase expressions via the NF-κB pathway.
An oncogenic retrovirus, human T-cell leukemia virus type I (HTLV-I), encodes an oncoprotein, Tax, which plays critical roles in leukemogenesis of adult T-cell leukemia/lymphoma (ATLL) through the pleiotropic actions such as transcriptional regulation, cell cycle control, and transformation. We have previously reported that PTEN and SHIP- 1, PIP3 inositol phosphatases that negatively regulate t...
متن کاملHuman T-cell leukemia virus type I induces adult T-cell leukemia: from clinical aspects to molecular mechanisms.
BACKGROUND Human T-cell leukemia virus type I (HTLV-I) is a causative virus of adult T-cell leukemia (ATL), HTLV-I-associated myelopathy/tropical spastic paraparesis, and HTLV-I-associated uveitis. ATL is a neoplastic disease of CD4-positive T lymphocytes that is characterized by pleomorphic tumor cells with hypersegmented nuclei, termed "flower cells." The mechanisms of leukemogenesis have not...
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